Member of Technical Staff (Computational Biology)

Experience: 0–4 years · Type: Full-time, On-site (Bengaluru)

The Mission

Mandrake Bio is a protein-design company building the next generation of programmable gene-editing enzymes. Its platform designs editors from scratch, pairing generative AI with first-principles biophysics and wet-lab validation to engineer the compactness, precision, and dynamic control that the highest-impact applications in agriculture and medicine demand. Founded in 2025 and headquartered in Bengaluru, India. Learn more at mandrake.bio.

We are a VC-backed, small, high-velocity applied research lab. We don't care about credentials; we care about proof of work, first-principles thinking, and the ability to ship.

What You'll Work On

• Build large-scale in-silico screening pipelines for protein/enzyme discovery, optimization, and functional characterization.
• Develop data-mining frameworks to extract, clean, and cluster large genomic, proteomic, and metagenomic datasets.
• Implement computational workflows for structure prediction, stability analysis, docking, and function annotation.
• Run high-throughput virtual screening and mutational characterization to nominate candidates for wet-lab validation.
• Integrate structural-biology tools with AI models for activity prediction and structure–function correlation.
• Partner tightly with AI and experimental teams to translate compute into validated tools — across therapeutic and agricultural programs.

You're a Great Fit If You

• Have strong footing in computational biology, protein engineering, or structural bioinformatics.
• Are fluent in Python / Biopython / PyRosetta / MDAnalysis / pandas / NumPy or equivalent.
• Have used protein modeling tools (AlphaFold, Rosetta, FoldX, docking suites, MD simulations).
• Understand sequence–structure–function relationships and biophysical determinants of stability/activity.
• Can build reproducible pipelines (Snakemake / Nextflow / Slurm / cloud) over large biological datasets.
• Think rigorously from first principles and thrive on high ownership.

Nice to Have

• Exposure to in-silico drug screening, virtual docking, or computational chemistry.
• Experience linking computational predictions to experimental readouts.

Why Mandrake

• Work on the frontier of AI × Biology — creating technologies that could redefine longevity, health, and the future of our planet.
• Join a small, high-velocity team where your ideas directly shape the company's direction and breakthroughs.
• Extremely high ownership. Own what you build end to end — from idea to model/experiment to deployment.
• We operate like an applied research lab — rapid iteration, deep focus, no bureaucracy.
• Work on real problems, not toy datasets. Build, publish, and innovate at the edge of science and engineering.
• Be part of something consequential. This isn't just another startup — it's the beginning of programmable life.

Logistics & How to Apply

Location: Indiranagar, Bengaluru — in-person, full-time, 6 days a week. We operate with the speed and focus of a wartime startup.

We don't care about degrees or credentials — send us proof of work. We encourage you to apply even if you don't meet every single qualification.

Apply Here · or write to careers@mandrakebio.com